139 Stanley Hall
Open Door Policy
Assistant Professor of Biology
- Public Health
- Quality Science
- Ph.D., University of Louisville
- B.S., Centre College
BIOL 461: Microbiology
BIOL 341: Cell Physiology
BIOL 382: Viral Disease Ecology
BIOL 112: Cells, Genes and Inheritance
BIOL 200: Epidemiology
August Term PLACE Program: The Science of Baking and Brewing
Lindsey McGee is a microbial evolutionary biologist interested in host range expansion of virus populations. She contributes to the core courses in the Biology Department, as well as upper-level Biology courses focusing on cellular and molecular biology in the context of ecological and evolutionary mechanisms.
Viruses differ in the numbers of host species they infect. Some strains successfully infect a range of species. Tobacco mosaic virus, for instance, can infect nine different plant families and at least 125 individual species. Others, such as poliovirus, infect only a single host. Host-range shifts in viruses and the evolutionary consequences of those shifts have implications to human health and agriculture. Natural shifts in host range have been the cause of some major epidemics in humans and other animals, such as HIV, the Spanish flu, and the recent Ebola virus epidemic.
Bacteriophages, which are viruses that infect bacterial cells and are among the best-characterized groups of organisms, serve as a great model system due to their small genome sizes, allowing for full-genome sequencing to elucidate the relationships between genotype, phenotype, and fitness. Students in my research group have worked to identify the natural host ranges of bacteriophages initially isolated on a single host, Escherichia coli strain C. These well-characterized viruses are all of the same family of Microviridae, but differ vastly in the number and type of bacterial species they can successfully infect. We have conducted a series of gene swap experiments of these closely related bacteriophage species with different host ranges to determine which genes are responsible for these variations in host range. Insights from these studies regarding the evolution and genomics of host range will inform our understanding of viral emergence.
American Society of Microbiology
Indiana Academy of Science